Of all the five sense, the one I would be most willing to give up is my sense of smell. Obviously it is hard to consider giving up even one of them but theses are the reasons why...
Of all senses I would be the most unwilling to part with my hearing. This is a touchy topic for me though because I know that it is highly likely that I will be deaf later in life. I am already deaf in my left ear and have been since birth, and my right ear isn't perfect either. Though I am fluent in sign language, I really fear living in total silence. Never having warning of things coming around corners, never being able to play my instruments and hear the music again (which is one of the biggest ways I relieve stress), and never hearing the voices of my friends again. The thought of that terrifies me.
The second biggest sense that I would have trouble giving up is my sight, though I know I could live without it. This is hard to contemplate getting rid of too though for different reasons than with my hearing. You see, my profession is that of a photographer. In order to do my job, I have to be able to see. If I couldn't see however, I would simply go back to school and become a history professor (I've always loved history). Now while I know I COULD live without my vision, I am unsure if I would WANT to. All the beautiful things I have seen in this life have made it hard to conceive being plunged into a world of darkness forever. The sight of mountains, nature, cities, art, and of Morgan and Elaine's faces... I never want to lose them.
Now that those two are explained and out of the way, it becomes much easier to narrow down the sense I want be most willing to surrender. Touch is most important to have to be able to do all the fine motor skills thing I do such as play guitar, repair objects using small tools, and operate the buttons on my camera. Without touch, I would lose the feeling of a hot bath, or a cool breeze, a massage, and the feeling of more "adult" activities.
This narrows down the list to smell and taste. This is a hard decision because they are so inextricably tied to one another. Without smell there is no taste and without taste there is no smell. I found that the lesser loss would be that of smell. There are too many delicious things I have tasted in the world for the rest to go untasted.