Some of this is habits picked up from working for VS. The rest is me just being nutzo.
I have two dressers, one tall 4-drawer one, and a long 9-drawer one, with the 3 middle drawers being smaller and behind a cute little door.
Long dresser:
Top left drawer - My everyday socks & underwear are in this drawer, the panties all individually folded like VS used to do. Socks are folded, one into the other, so that only the very ends of the toes stick out. They can't tangle easily this way - important, because I have a lot of knee socks. The socks are tossed in around the panties.
Middle & Bottom left drawer - This is where my sexy clothes & lingerie that I use for camming are kept. I have everything folded fairly small, and sets are folded with all the smaller components (panties, maid aprons, gloves, etc.) in the folds of the larger piece. Everything's in a stack of "what it is": sleepshirts, skirts, shorts, sets, vests, tops, nighties.
Top middle drawer - shapewear, including control pantyhose and Spanx. Each type of item neatly folded and stacked for easy retrieval.
True middle drawer (like True Neutral, get it?) - Camming/sexy panties. Folded, with the fronts facing to the left because the drawer works best that way. Panties I'm going to sell are between the other panties and the front of the drawer, not really folded or anything.
Bottom middle drawer - Slips, folded neatly. I only have two half-slips right now, but that collection will grow.
Right top drawer - Camming bras and bikini tops, clasped and laying flat, nestled inside one another.
Middle right drawer - Hosiery and accessories. Tights folded and in one pile, fishnet tights/pantyhose/whate ver they are in another, thigh-highs and stockings folded in pairs in another, garter belts folded and stacked, and trouser socks/knee-high hosiery (not socks) folded like socks.
Bottom right drawer - Weather-determined items. Hats, gloves, scarves, thermals, my husband's swim trunks because I haven't done anything with any of his clothes (aside from throwing away his underwear) yet.
Tall dresser:
Top drawer - Casual clothes that I don't want to waste room in the closet with.
Second drawer - Everyday bras, clasped and standing up (they're really big and can't lay down well), nestled inside each other.
Third drawer - Kink/sex toys/books.
Bottom drawer - Clothes that are too small.
Bra tip: Never, ever, ever! Fold the cups of a bra into one another. This causes the material of the bra cup to deteriorate, causing the bra to be worn out, lose support/shape ability, create odd lines/shapes under clothing, and need to be replaced sooner than normal. As someone whose cup size requires the purchase of $60+ bras, I go nuts when I see people abuse their bras like that!