"Let's shoot dis fucka." - Bela Lugosi (as played by Martin Landau), Ed Wood

Oh, I have so many!

"Your mother puts license plates in your underwear? How do you sit?" (Val Kilmer as Chris Knight in Real Genius)

"Chinese...Japanese... Dirty Knees...Look at THESE!" (Sherry Moon Zombie as Baby in The Devil's Rejects)

"It's always going to be something with you, isn't it Joe?" (Joe vs. the Volcano)

"All you have to do is follow three simple rules. One, never underestimate your opponent. Expect the unexpected. Two, take it outside. Never start anything inside the bar unless it's absolutely necessary. And three, be nice." (Patrick Swayze as Dalton in Road House)

And the list goes on and on and on and on and on...but here's one more for the road:

"No more Mr. cuddly toy. I'm not hanging around here to be a whipping boy for ganja Grace and captain Nicky the fuckin' lobster queen." (Craig Ferguson as Matthew Stewart in Saving Grace)

"when this baby hits 88 mph you're going to see some serious shit."

"GO ahead, Make my Day"

Oh, almost forgot -

"Just fear me, love me, do as I say, and I will be your slave." - Jareth (as played by David Bowie), Labyrinth

"Come away O human child / To the waters and the wild / With a fairy hand in hand / For the world's more full of weeping / Than you can understand." - Dr. Know, AI: Artificial Intelligence

"What are people like on the inside?"
"Inside most people there's a feeling of being separate, separated from everything."
"And?"
"And they're not. They're part of absolutely everyone, and everything." - Linsey and Powder, Powder.

"If a bullet should enter my brain, let that bullet destroy every closet door... And that's all. I ask for the movement to continue. Because it's not about personal gain, not about ego, not about power... it's about the "us's" out there. Not only gays, but the Blacks, the Asians, the disabled, the seniors, the us's. Without hope, the us's give up - I know you cannot live on hope alone, but without it, life is not worth living." - Harvey Milk, Milk

So many great ones... Let's see...

"They're coming to get you, Barbara!" -Night of the Living Dead

"We're coming to get you, Barbara!" -Shaun of the Dead (Best offhand reference in that movie, I think).

"I know what you're thinking. "Did he fire six shots, or only five?" Well, to tell you the truth, in all this excitement, I kind of lost track myself. But being as this is a .44 Magnum, the most powerful handgun in the world, and would blow your head clean off, you've got to ask yourself one question: Do I feel lucky? Well, do ya, punk?" - Dirty Harry

"Put your hands on the desk. Palms down." - Secretary

"My nose isn't bleeding because I'm horny." - Happiness of the Katakuris

Well I have to agree with the Yoda quote above, but the one I use the most are probably the two lines or so from the little penguin that sounds stoned in the aquarium from the movie Happy Feet.

"Try the water Dave...it's really real."
and
"You're in heaven Dave...penguin heaven."

Dunno why but I love that little penguin. xD

video clip of epic penguiny goodness

"You're a wizard Harry!" .... Harry Potter is the best series in the world!