hmm ... as far as an intimate relationship and my soulmate, that's a hard question to really answer. perhaps it is because i believe i'm with my soulmate and feel like he's irreplacable. for my own body and household i want as little medical interference as possible - so a gender transformation surgical procedure would be very difficult for me to be ok with. however, if one day my man wanted to walk around in a dress and put on makeup - whatever i'm fine with that.
as far as friendships, acquaintanceships, the millions of people i may come in contact but never really "know" - do what you've gotta do to be happy, your life is yours to do with as you choose, and the person who is your soulmate will agree with the choices you've made to be happy.